Dataset

Kisspeptin signaling in astrocytes centrally modulates the reproductive axis

Encarnacion Torres^1,2,3, Giulliana Pellegrino⁴, Inmaculada Velasco^1,2,3, Antonio Carlos Fuentes-Fayos^1,2,3, Melissa Granados-Rodriguez^1,2,3, Adrián Coutteau-Robles⁴, Amandine Legrand⁴, Cecilia Perdices-Lopez^1,2,3, Silvia Leon^1,2,3, Shel H Yeo⁵, Stephen Manchishi⁵, María Jesús Sanchez-Tapia^1,2,3, Rafael Pineda^1,2,3, Juan Roa^1,2,3,6, Jesús Argente^6,7,8, Raúl M. Luque^1,2,6, Vicent Prevot⁴, Julie Chowen^6,7, Ariane Sharif⁴, William H. Colledge⁵, Manuel Tena-Sempere^1,2,3,6,9, Antonio Romero^1,2,3

¹Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
²Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain
³Hospital Universitario Reina Sofía, Córdoba, Spain
⁴Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France
⁵Reproductive Physiology Group, Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
⁶CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
⁷Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, and IMDEA Food Institute, CEI UAM + CSIC MAdrid, Madrid, Spain
⁸Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain
⁹Institute of Biomedicine, University of Turku, Finland

DOI: 10.12751/g-node.94ew7e BROWSE REPOSITORY BROWSE ARCHIVE DOWNLOAD ARCHIVE (ZIP 25 MiB)

Published 28 Dec. 2022 | License Creative Commons CC0 1.0 Public Domain Dedication

A newer version of this dataset is available at https://doi.org/10.12751/g-node.z9q4zs

Description

Reproduction is safeguarded by multiple, often cooperative regulatory networks. Kisspeptin signaling, via Kiss1r, plays a fundamental role in reproductive control, primarily by regulation of hypothalamic GnRH neurons. We disclose herein a pathway for direct kisspeptin actions in astrocytes that contribute to central reproductive modulation.

Keywords

| Kisspeptin-signaling | Astrocytes | Reproduction |

References

E. Torres, G. Pellegrino, I. Velasco, A.C. Fuentes-Fayos, M. Granados-Rodríguez, A. Coutteau-Robles, A. Legrand, C. Perdices-Lopez, S. Leon, S.H. Yeo, S.M. Manchishi, M.J. Sánchez-Tapia, R. Pineda, J. Roa, J. Argente, R.M. Luque, V. Prevot, J. Chowen, A. Sharif, W.H. Colledge, M. Tena-Sempere, A. Romero-Ruiz: Kisspeptin signaling in astrocytes centrally modulates the reproductive axis.

Funding

Agencia Estatal de Investigación, Spain co-funded with EU funds from FEDER Program; BFY2017-83934-P
Agencia Estatal de Investigación, Spain co-funded with EU funds from FEDER Program; PID2019-105564RB-I00
Agencia Estatal de Investigación, Spain co-funded with EU funds from FEDER Program; PID2020-118660GB-I00
Flexi-Met, Instituto de Salud Carlos III, Ministerio de Sanidad, Spain Project PIE-14-00005 (
Junta de Andalucía, Spain Projects P12-FQM-01943 and P18-RT-4093
Universidad de Córdoba-FEDER Project 1254821
BBSRC Project Grant BB/K003178/1

Citation

Torres E, Pellegrino G, Velasco I, Fuentes-Fayos AC, Granados-Rodriguez M, Coutteau-Robles A, Legrand A, Perdices-Lopez C, Leon S, Yeo SH, Manchishi S, Sanchez-Tapia MJ, Pineda R, Roa J, Argente J, Luque RM, Prevot V, Chowen J, Sharif A, Colledge WH, Tena-Sempere M, Romero A (2022) Kisspeptin signaling in astrocytes centrally modulates the reproductive axis. G-Node. https://doi.org/10.12751/g-node.94ew7e