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Data from: Theta but not gamma oscillations in area V4 depend on input from primary visual cortex

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  1. 1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Deutschordenstraße 46, 60528 Frankfurt a. M., Germany; Institute of Neuroscience, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK; Epilepsy Center Frankfurt Rhine-Main, Center of Neurology and Neurosurgery, Goethe University, Schleusenweg 2-16, 60528 Frankfurt a.M., Germany
  2. 2Department of Psychology, Vanderbilt University, 111 21st Avenue South, 301 Wilson Hall, Nashville, TN 37240, USA; Department of Brain and Cognitive Sciences - University of Rochester, Meliora Hall, University of Rochester, Rochester, NY 14627
  3. 3Department of Psychology, Vanderbilt University, 111 21st Avenue South, 301 Wilson Hall, Nashville, TN 37240, USA; Princeton Neuroscience Institute, Princeton University, Washington Rd, Princeton, New Jersey 08544, USA
  4. 4Laboratory of Neuropsychology, NIMH, Convent Drive 49, Bethesda, MD 20892, USA
  5. 5Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Deutschordenstraße 46, 60528 Frankfurt a. M., Germany
  6. 6Laboratory of Neuropsychology, NIMH, Convent Drive 49, Bethesda, MD 20892, USA; Neurophysiology Imaging Facility, NIMH, NINDS & NEI, 49 Convent Drive, Bethesda, MD 20892, USA
  7. 7Department of Psychology, Vanderbilt University, 111 21st Avenue South, 301 Wilson Hall, Nashville, TN 37240, USA
  8. 8Institute of Neuroscience, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK; Faculty of Science and Medicine, Chemin du Musée 5, 1700 Fribourg, Switzerland

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Published 24 Oct. 2020 | License CC BY-NC-SA 4.0

New dataset version

A newer version of this dataset is available at https://doi.org/10.12751/g-node.nb4nnp

Description

Theta (3-9 Hz) and gamma (30-100 Hz) oscillations have been observed at different levels along the hierarchy of cortical areas and across a wide set of cognitive tasks. In the visual system, the emergence of both rhythms in primary visual cortex (V1) and mid-level cortical areas V4 have been linked with variations in perceptual reaction times [1–5]. Based on analytical methods to infer causality in neural activation patterns, it was concluded that gamma and theta oscillations might both reflect feedforward sensory processing from V1 to V4 [6–10]. Here we report on experiments in macaque monkeys in which we experimentally assessed the presence of both oscillations in the neural activity recorded from multi-electrode arrays in V1 and V4 before and after a permanent V1-lesion. With intact cortex theta and gamma oscillations could be reliably elicited in V1 and V4 when monkeys viewed a visual contour illusion and showed phase-to- amplitude coupling. Laminar analysis in V1 revealed that both theta and gamma oscillations occurred primarily in the supragranular layers, the cortical output compartment of V1. However, there was a clear dissociation between the two rhythms in V4 that became apparent when the major feedforward input to V4 was removed by lesioning V1: While V1 lesioning eliminated V4 theta, it had little effect on V4 gamma power except for delaying its emergence by >100 ms. These findings suggest that theta is more tightly associated with feedforward processing than gamma and pose limits on the proposed role of gamma as a feedforward mechanism.

Keywords

| neuroscience | visual cortex | primary visual cortex (V1) | V4 | oscillations | rhythms | theta | gamma | lesion | feedforward | feedback |

References

  • R. Kienitz, M.A. Cox, K. Dougherty, R.C. Saunders, J.T. Schmiedt, D.A. Leopold, A. Maier, M.C. Schmid, Theta but not gamma oscillations in area V4 depend on input from primary visual cortex. Current Biology, 2020

Funding

  • National Institute of Mental Health ZIA-MH002838
  • National Eye Institute training grant 2T32 EY007135-21
  • Alfred P. Sloan Fellowship
  • The Whitehall Foundation
  • The Knights Templar Eye Foundation career starter
  • The National Eye Institute 1R01EY027402-02
  • DFG Emmy Noether grant 2806/1
  • ERC OptoVision 637638

Citation

Kienitz R, Cox MA, Dougherty K, Saunders RC, Schmiedt JT, Leopold DA, Maier A, Schmid MC (2020) Data from: Theta but not gamma oscillations in area V4 depend on input from primary visual cortex. G-Node. https://doi.org/10.12751/g-node.kmk7oz