Dataset
The dorsal and ventral hippocampus contribute differentially to spatial working memory and spatial coding in the prefrontal cortex
- 1Ernst Strüngmann Institute for Neuroscience
- 2Institute for Neurophysiology, Goethe University Frankfurt
DOI: 10.12751/g-node.ls2xxj BROWSE REPOSITORY BROWSE ARCHIVE DOWNLOAD ARCHIVE (ZIP 272 MiB)
Published 11 Mar. 2025 | License Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License
Description
The hippocampus (HPC) supports spatial working memory (SWM) through its interactions with the prefrontal cortex (PFC). However, it is not clear whether and how the dorsal (dHPC) and ventral (vHPC) poles of the HPC make distinct contributions to SWM and whether they differentially influence the PFC. To address this question, we optogenetically silenced the dHPC or the vHPC while simultaneously recording from the PFC of mice performing a SWM task. We found that whereas both HPC subregions were necessary during the encoding phase of the task, only the dHPC was necessary during the choice phase. Silencing of either subregion altered the spatial firing patterns of PFC neurons. However, only silencing of the vHPC affected their coding of spatial goals. These results thus reveal distinct contributions of the dorsal and ventral HPC poles to SWM and the coding of behaviorally-relevant spatial information by PFC neurons.
Keywords
| Spatial working memory | Prefrontal cortex | Hippocampus |References
- S.S. Babl, T. Sigurdsson (2025): The dorsal and ventral hippocampus contribute differentially to spatial working memory and spatial coding in the prefrontal cortex, PLOS Biology.