Dataset

Kisspeptin signaling in astrocytes centrally modulates the reproductive axis

Encarnacion Torres^1,2,3, Giulliana Pellegrino⁴, Melissa Granados-Rodriguez^1,2,3, Antonio Carlos Fuentes-Fayos^1,2,3, Inmaculada Velasco^1,2,3, Adrián Coutteau-Robles⁴, Amandine Legrand⁴, Marya Shanabrough⁵, Cecilia Perdices-Lopez^1,2,3, Silvia Leon^1,2,3, Shel H Yeo⁶, Stephen Manchishi⁶, María Jesús Sanchez-Tapia^1,2,3, Victor Manuel Navarro⁷, Rafael Pineda^1,2,3, Juan Roa^1,2,3,8, Fred Naftolin⁹, Jesús Argente^8,10,11, Raúl M. Luque^1,2,8, Julie Chowen^8,10, Tamas L. Horvath⁵, Vicent Prevot⁴, Ariane Sharif⁴, William H. Colledge⁶, Manuel Tena-Sempere^1,2,3,8, Antonio Romero^1,2,3

¹Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
²Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain
³Hospital Universitario Reina Sofía, Córdoba, Spain
⁴Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France
⁵Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA
⁶Reproductive Physiology Group, Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
⁷Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, USA
⁸CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
⁹Centro de Fecundacion In Vitro Angela Palumbo (FIVAP), La Laguna, Spain
¹⁰Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, and IMDEA Food Institute, CEI UAM + CSIC MAdrid, Madrid, Spain
¹¹Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain

DOI: 10.12751/g-node.z9q4zs BROWSE REPOSITORY BROWSE ARCHIVE DOWNLOAD ARCHIVE (ZIP 25 MiB)

Published 03 Apr. 2024 | License Creative Commons CC0 1.0 Public Domain Dedication

Description

Reproduction is safeguarded by multiple, often cooperative regulatory networks. Kisspeptin signaling, via Kiss1r, plays a fundamental role in reproductive control, primarily by regulation of hypothalamic GnRH neurons. We disclose herein a pathway for direct kisspeptin actions in astrocytes that contribute to central reproductive modulation.

Keywords

| Kisspeptin-signaling | Astrocytes | Reproduction |

References

E. Torres, G. Pellegrino, I. Velasco, A.C. Fuentes-Fayos, M. Granados-Rodríguez, A. Coutteau-Robles, A. Legrand, M. Shanabrough, C. Perdices-Lopez, S. Leon, S.H. Yeo, S.M. Manchishi, M.J. Sánchez-Tapia, R. Pineda, J. Roa, F. Naftolin, J. Argente, R.M. Luque, V. Prevot, J. Chowen, T.L. Horvath, A. Sharif, W.H. Colledge, M. Tena-Sempere, A. Romero-Ruiz: Kisspeptin signaling in astrocytes centrally modulates the reproductive axis

Funding

Agencia Estatal de Investigación, Spain, co-funded with EU funds from FEDER Program BFY2017-83934-P
Agencia Estatal de Investigación, Spain, co-funded with EU funds from FEDER Program PID2019-105564RB-I00
Agencia Estatal de Investigación, Spain, co-funded with EU funds from FEDER Program PID2020-118660GB-I00
Flexi-Met, Instituto de Salud Carlos III, Ministerio de Sanidad, Spain Project PIE-14-00005
Junta de Andalucía, Spain Projects P12-FQM-01943 and P18-RT-4093
Universidad de Córdoba-FEDER Project 1254821
BBSRC Project Grant BB/K003178/1

Citation

Torres E, Pellegrino G, Granados-Rodriguez M, Fuentes-Fayos AC, Velasco I, Coutteau-Robles A, Legrand A, Shanabrough M, Perdices-Lopez C, Leon S, Yeo SH, Manchishi S, Sanchez-Tapia MJ, Navarro VM, Pineda R, Roa J, Naftolin F, Argente J, Luque RM, Chowen J, Horvath TL, Prevot V, Sharif A, Colledge WH, Tena-Sempere M, Romero A (2024) Kisspeptin signaling in astrocytes centrally modulates the reproductive axis. G-Node. https://doi.org/10.12751/g-node.z9q4zs